First: 10-fold Activity Boost! mRNA Technology Takes a Key Step Forward

Nagoya University in Japan, in collaboration with Fujifilm Corporation, has developed a novel lipid nanoparticle (LNP) that, for the first time, enables the efficient delivery of capped circular RNA (Cap-cirRNA) into animals. The approach achieves a 10-fold increase in activity with minimal inflammation, opening a new door for the next generation of long-acting mRNA therapies. The research was published in the latest issue of the journal *Cell Biomaterials*.